Introduction – Company Background
GuangXin Industrial Co., Ltd. is a specialized manufacturer dedicated to the development and production of high-quality insoles.
With a strong foundation in material science and footwear ergonomics, we serve as a trusted partner for global brands seeking reliable insole solutions that combine comfort, functionality, and design.
With years of experience in insole production and OEM/ODM services, GuangXin has successfully supported a wide range of clients across various industries—including sportswear, health & wellness, orthopedic care, and daily footwear.
From initial prototyping to mass production, we provide comprehensive support tailored to each client’s market and application needs.
At GuangXin, we are committed to quality, innovation, and sustainable development. Every insole we produce reflects our dedication to precision craftsmanship, forward-thinking design, and ESG-driven practices.
By integrating eco-friendly materials, clean production processes, and responsible sourcing, we help our partners meet both market demand and environmental goals.
Core Strengths in Insole Manufacturing
At GuangXin Industrial, our core strength lies in our deep expertise and versatility in insole and pillow manufacturing. We specialize in working with a wide range of materials, including PU (polyurethane), natural latex, and advanced graphene composites, to develop insoles and pillows that meet diverse performance, comfort, and health-support needs.
Whether it's cushioning, support, breathability, or antibacterial function, we tailor material selection to the exact requirements of each project-whether for foot wellness or ergonomic sleep products.
We provide end-to-end manufacturing capabilities under one roof—covering every stage from material sourcing and foaming, to precision molding, lamination, cutting, sewing, and strict quality control. This full-process control not only ensures product consistency and durability, but also allows for faster lead times and better customization flexibility.
With our flexible production capacity, we accommodate both small batch custom orders and high-volume mass production with equal efficiency. Whether you're a startup launching your first insole or pillow line, or a global brand scaling up to meet market demand, GuangXin is equipped to deliver reliable OEM/ODM solutions that grow with your business.
Customization & OEM/ODM Flexibility
GuangXin offers exceptional flexibility in customization and OEM/ODM services, empowering our partners to create insole products that truly align with their brand identity and target market. We develop insoles tailored to specific foot shapes, end-user needs, and regional market preferences, ensuring optimal fit and functionality.
Our team supports comprehensive branding solutions, including logo printing, custom packaging, and product integration support for marketing campaigns. Whether you're launching a new product line or upgrading an existing one, we help your vision come to life with attention to detail and consistent brand presentation.
With fast prototyping services and efficient lead times, GuangXin helps reduce your time-to-market and respond quickly to evolving trends or seasonal demands. From concept to final production, we offer agile support that keeps you ahead of the competition.
Quality Assurance & Certifications
Quality is at the heart of everything we do. GuangXin implements a rigorous quality control system at every stage of production—ensuring that each insole meets the highest standards of consistency, comfort, and durability.
We provide a variety of in-house and third-party testing options, including antibacterial performance, odor control, durability testing, and eco-safety verification, to meet the specific needs of our clients and markets.
Our products are fully compliant with international safety and environmental standards, such as REACH, RoHS, and other applicable export regulations. This ensures seamless entry into global markets while supporting your ESG and product safety commitments.
ESG-Oriented Sustainable Production
At GuangXin Industrial, we are committed to integrating ESG (Environmental, Social, and Governance) values into every step of our manufacturing process. We actively pursue eco-conscious practices by utilizing eco-friendly materials and adopting low-carbon production methods to reduce environmental impact.
To support circular economy goals, we offer recycled and upcycled material options, including innovative applications such as recycled glass and repurposed LCD panel glass. These materials are processed using advanced techniques to retain performance while reducing waste—contributing to a more sustainable supply chain.
We also work closely with our partners to support their ESG compliance and sustainability reporting needs, providing documentation, traceability, and material data upon request. Whether you're aiming to meet corporate sustainability targets or align with global green regulations, GuangXin is your trusted manufacturing ally in building a better, greener future.
Let’s Build Your Next Insole Success Together
Looking for a reliable insole manufacturing partner that understands customization, quality, and flexibility? GuangXin Industrial Co., Ltd. specializes in high-performance insole production, offering tailored solutions for brands across the globe. Whether you're launching a new insole collection or expanding your existing product line, we provide OEM/ODM services built around your unique design and performance goals.
From small-batch custom orders to full-scale mass production, our flexible insole manufacturing capabilities adapt to your business needs. With expertise in PU, latex, and graphene insole materials, we turn ideas into functional, comfortable, and market-ready insoles that deliver value.
Contact us today to discuss your next insole project. Let GuangXin help you create custom insoles that stand out, perform better, and reflect your brand’s commitment to comfort, quality, and sustainability.
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Are you looking for a trusted and experienced manufacturing partner that can bring your comfort-focused product ideas to life? GuangXin Industrial Co., Ltd. is your ideal OEM/ODM supplier, specializing in insole production, pillow manufacturing, and advanced graphene product design.
With decades of experience in insole OEM/ODM, we provide full-service manufacturing—from PU and latex to cutting-edge graphene-infused insoles—customized to meet your performance, support, and breathability requirements. Our production process is vertically integrated, covering everything from material sourcing and foaming to molding, cutting, and strict quality control.Customized sports insole ODM Thailand
Beyond insoles, GuangXin also offers pillow OEM/ODM services with a focus on ergonomic comfort and functional innovation. Whether you need memory foam, latex, or smart material integration for neck and sleep support, we deliver tailor-made solutions that reflect your brand’s values.
We are especially proud to lead the way in ESG-driven insole development. Through the use of recycled materials—such as repurposed LCD glass—and low-carbon production processes, we help our partners meet sustainability goals without compromising product quality. Our ESG insole solutions are designed not only for comfort but also for compliance with global environmental standards.Arch support insole OEM factory from Taiwan
At GuangXin, we don’t just manufacture products—we create long-term value for your brand. Whether you're developing your first product line or scaling up globally, our flexible production capabilities and collaborative approach will help you go further, faster.Taiwan ODM expert for comfort products
📩 Contact us today to learn how our insole OEM, pillow ODM, and graphene product design services can elevate your product offering—while aligning with the sustainability expectations of modern consumers.Vietnam pillow ODM development service
Messenger RNA (blue) is protected from degradation (yellow). Credit: MPI MOPH The discovery of the first mRNA-stabilizing substance could pave the way for groundbreaking advancements in the development of innovative mRNA therapies. mRNA carries the most valuable cellular information — the chemical blueprint for protein production—from the nucleus to the cytoplasm. Once it delivers its message to the protein-producing machinery in the cytoplasm, it is no longer required and is broken down by exonucleases. Depending on how long the mRNA remains in the cytoplasm, more or less of a protein is produced – be it health-promoting or disease-causing. The regulation of mRNA levels is one of the most promising strategies in the emerging field of RNA-based therapeutics. How to protect the messenger The team around Peter ‘t Hart has now developed a new strategy to extend the lifespan of mRNA by protecting it from its dismantling. Interestingly, mRNA is not particularly stable by nature and would be degraded prematurely without molecular caps protecting the two mRNA ends. At its so-called 3’ end mRNA is equipped with a polyadenine tail with an average length of 200 nucleotides. But even this shield does not last long – the average half-life of mRNA is only 7 hours. In a process called deadenylation, the target mRNA is recruited by RNA-binding proteins to the protein complex CCR4-NOT, which removes one adenine after the other. Regulation of deadenylation by the NOT9 subunit of the CCR4-NOT complex. Credit: MPI MOPH And this is precisely where the scientists’ new strategy comes in. Based on the structure of the mRNA-binding protein, they have developed a large peptide, that can block the interaction of the CCR4-NOT complex with the target mRNA. Large peptides, however, have problems overcoming (crossing) cellular barriers, what they have to do if they are to be used as drugs. By revealing the 3D-structure of the peptide-inhibitor bound to the target the chemists were able to make modifications, that improved the cell permeability of the peptide. Increasing the stability of potentially health-promoting proteins The scientists were able to take their work even one step further and demonstrate the potential of their strategy in cellular assays. Treating cells with the peptide stabilized the polyadenine tails of two potential health-promoting proteins: a tumor suppressor, which could have beneficial effects in cancer, and a nuclear receptor, whose increasing levels could help to treat various aging-related diseases. “The concept of stabilizing beneficial mRNAs by blocking their deadenylation has not yet been explored. Since almost all mRNAs undergo this process, blocking them can be used to develop new drugs that offer a new way to treat diseases where other strategies have failed,” says ‘t Hart. His group is currently working on the development of further inhibitors against other components of the deadenylation machinery. Reference: “Stapled Peptides as Inhibitors of mRNA Deadenylation” by Sunit Pal, Ilja Gordijenko, Stefan Schmeing, Somarghya Biswas, Yasemin Akbulut, Raphael Gasper and Peter ‘t Hart, 25 September 2024, Angewandte Chemie International Edition. DOI: 10.1002/anie.202413911
Researchers Pim Bongaerts and Norbert Englebert on a collection dive. Credit: © David Whillas Researchers say that our framework for classifying coral species needs to be expanded to capture ecological diversity and protect reef environments. In recent years, advancements in DNA sequencing have exposed a large amount of hidden diversity in reef-building corals: species that appear identical to one another but are genetically distinct. Typically ignored as they are invisible to the naked eye, a team of researchers at the California Academy of Sciences and The University of Queensland, along with over a dozen international collaborators, is taking a more holistic approach to understand these hidden species by investigating overlooked ecological differences that have wide-ranging implications for the vulnerability and resilience of reef-building corals. The team hopes that their findings, published today in Current Biology, will lead to a more nuanced consideration of coral diversity, that incorporates more aspects than appearance alone, to drive more strategic conservation planning. “We know we are greatly underestimating the true number of coral species because of this hidden diversity,” says lead author and Academy Curator Pim Bongaerts. “In our study, we provide one of the first clear examples of how coral species that look identical can be very different in terms of their ecology and physiology, from when they reproduce to what depths they prefer. This means that our current framework for classifying reef-building corals based primarily on morphology is limiting our ability to understand and protect them.” Academy researcher and lead author Pim Bongaerts deploys a remotely operated vehicle. Credit: The Ocean Agency XL Catlin Seaview Survey © Richard Vevers By conducting one of the most extensive genomic studies of a coral species to date, which involved obtaining DNA samples from more than 1,400 individuals, the researchers began their study by discovering that the “serpent coral” (Pachyseris speciosa)—one of the most widespread corals across the Indo-Pacific—is actually four different species that evolved millions of years ago. To their surprise, these species were indistinguishable from each other, even at a microscopic level, sparking the researchers to take it a step further and look for ecological differences that may have been missed when they were thought to be one species. Using remotely-operated vehicles and specialized deep diving gear, the researchers investigated corals from shallow depths down to 80 meters beneath the surface—into the vastly understudied mesophotic zone of coral reefs. They discovered that although individuals from each species could be found over the entire range of depths, they had distinct depths where they were most abundant, with corresponding differences in physiological traits such as protein content that affect their ability to survive and thrive at their preferred depths. Researcher Norbert Englebert collects samples from a Pachyseris speciosa colony. Credit: Pim Bongaerts © California Academy of Sciences “Knowing what corals thrive where and at which depths is crucial for reef conservation,” says study co-author at The University of Queensland Professor Ove Hoegh-Guldberg. “Most marine protected areas only protect shallow reefs, which means that hidden species at mesophotic depths are being overlooked by current conservation strategies. We need to give this gap in protection some further thought.” Besides the physiological and depth differences, the research team also developed a rapid DNA test to be able to identify these species in the field and monitor their reproduction. They discovered that there were differences between the species in the timing of broadcast spawning—the mechanism whereby environmental cues trigger an entire population of corals to synchronously release their gametes. This staggered spawning may provide an explanation for the lack of interbreeding between the species (a common occurrence for many corals) despite living side-by-side on the reef. Coral reefs are important, but fragile, environments that support an abundance of life (such as this silvertip shark!) Credit: Pim Bongaerts © California Academy of Sciences “For years we have asked ourselves about the relevance of this hidden diversity, wondering if we are missing something important,” says Academy researcher and study co-author Alejandra Hernández-Agreda. “By using all of the tools at our disposal to analyze not just the morphology, but all these other aspects of these species as well, we now show how this hidden diversity can mask major differences in these species that could translate to their ability to cope with the rapidly changing conditions of our world’s oceans.” Ultimately, the researchers hope that their findings reveal the importance of taking a holistic approach to understanding these hidden species that appear identical, but may be harboring key differences that impact global conservation efforts. “At a moment when reefs around the world are experiencing rapid degradation,” Bongaerts says, “it is critical to start capturing this hidden diversity—not only of species, but of how they live and function—to improve our understanding and ability to protect these fragile ecosystems. Reference: “Morphological stasis masks ecologically divergent coral species on tropical reefs” by Pim Bongaerts, Ira R. Cooke, Hua Ying, Dagmar Wels, Stijn den Haan, Alejandra Hernandez-Agreda, Christopher A. Brunner, Sophie Dove, Norbert Englebert, Gal Eyal, Sylvain Forêt, Mila Grinblat, Kyra B. Hay, Saki Harii, David C. Hayward, Yu Lin, Morana Mihaljevic, Aurelie Moya, Paul Muir, Frederic Sinniger, Patrick Smallhorn-West, Gergely Torda, Mark A. Ragan, Madeleine J.H. van Oppen and Ove Hoegh-Guldberg, 2 April 2021, Current Biology. DOI: 10.1016/j.cub.2021.03.028
Biologists and paleontologists have long debated the origins of North American porcupines, with DNA suggesting a 10 million year history, while fossils indicate they may have evolved only 2.5 million years ago. A new study, leveraging a nearly complete porcupine skeleton found in Florida, has clarified this timeline by comparing anatomical differences with South American species, concluding North American porcupines are indeed an ancient group. The study, supported by a unique college course, also explored the broader migratory and evolutionary patterns of porcupines and other mammals across continents, highlighting how environmental changes shaped their adaptations and survival. Credit: Florida Museum photo by Jeff Gage New findings from a complete porcupine skeleton in Florida reveal a much earlier origin for North American porcupines, predating the Isthmus of Panama, and suggest a mixed evolutionary lineage with traits of both North and South American species. There’s a longstanding debate simmering among biologists who study porcupines. In Central and South America, there are 16 species of porcupines, while North America has just one. Genetic data indicates that this lone North American porcupine is part of a lineage that dates back 10 million years. However, fossil records provide a contrasting narrative, suggesting that they might have evolved only 2.5 million years ago, at the beginning of the ice ages. A new study published in the journal Current Biology claims to have reconciled the dispute, thanks to an exceptionally rare, nearly complete porcupine skeleton discovered in Florida. The authors reached their conclusion by studying key differences in bone structure between North and South American porcupines, but getting there wasn’t easy. It took an entire class of graduate and undergraduate students and several years of careful preparation and study. “Even for a seasoned curator with all the necessary expertise, it takes an incredible amount of time to fully study and process an entire skeleton,” said lead author Natasha Vitek. While studying as a doctoral student at the Florida Museum of Natural History, Vitek teamed up with vertebrate paleontology curator Jonathan Bloch to create a college course in which students got hands-on research experience by studying porcupine fossils. Ancient radiation gave rise to the world’s largest rodents Porcupines are a type of rodent, and their ancestors likely originated in Africa more than 30 million years ago. Their descendants have since wandered into Asia and parts of Europe by land, but their journey to South America is a particularly defining event in the history of mammals. They crossed the Atlantic Ocean — likely by rafting — when Africa and South America were much closer together than they are today. They were the first rodents to ever set foot on the continent, where they evolved into well-known groups like guinea pigs, chinchillas, capybaras, and porcupines. Some took on giant proportions. There were lumbering, rat-like animals up to five feet long, equipped with a tiny brain that weighed less than a plum. Extinct relatives of the capybara grew to the size of cows. Porcupines remained relatively small and evolved adaptations for life in the treetops of South America’s lush rainforests. Today, they travel through the canopy with the aid of long fingers capped with blunt, sickle-shaped claws perfectly angled for gripping branches. Many also have long, prehensile tails capable of bearing their weight, which they use while climbing and reaching for fruit. North (left) and South (right) American porcupines have been on separate evolutionary trajectories for as long as 10 million years. Credit: Florida Museum photo by Kristen Grace Despite their excellent track record of getting around, South America was a dead end for many millions of years. A vast seaway with swift currents separated North and South America, and most animals were unable to cross — with a few notable exceptions. Beginning about 5 million years ago, the Isthmus of Panama rose above sea level, cutting off the Pacific from the Atlantic. This land bridge became the ancient equivalent of a congested highway a few million years later, with traffic flowing in both directions. Prehistoric elephants, saber-toothed cats, jaguars, llamas, peccaries, deer, skunks, and bears streamed from North America to South. The reverse trek was made by four different kinds of ground sloths, oversized armadillos, terror birds, capybaras, and even a marsupial. The two groups met with radically different fates. Those mammals migrating south did fairly well; many became successfully established in their new tropical environments and survived to the present. But nearly all lineages that ventured north into colder environments have gone extinct. Today, there are only three survivors: the nine-banded armadillo, the Virginia opossum, and the North American porcupine. New fossils catch evolution in the act Animals that traveled north had to contend with new environments that bore little resemblance to the ones they left behind. Warm, tropical forests gave way to open grasslands, deserts, and cold deciduous forests. For porcupines, this meant coping with brutal winters, fewer resources and coming down from the trees to walk on land. They still haven’t quite gotten the hang of the latter; North American porcupines have a maximum ground speed of about 2 mph. South American porcupines are equipped with a menacing coat of hollow, overlapping quills, which offer a substantial amount of protection but do little to regulate body temperature. North American porcupines replaced these with a mix of insulating fur and long, needle-like quills that can be raised when they feel threatened. They also had to modify their diet, which changed the shape of their jaw. “In winter, when their favorite foods are not around, they will bite into tree bark to get at the softer tissue underneath. It’s not great food, but it’s better than nothing,” Vitek said. “We think this type of feeding selected for a particular jaw structure that makes them better at grinding.” They also lost their prehensile tails. Although North American porcupines still like climbing, it’s not their forte. Museum specimens often show evidence of healed bone fractures, likely caused by falling from trees. Many of these traits can be observed in fossils. The problem is there aren’t many fossils to go around. According to Vitek, most are either individual teeth or jaw fragments, and researchers often lump them in with South American porcupines. Those that are considered to belong to the North American group lack the critical features that would provide paleontologists with clues to how they evolved. So when Florida Museum paleontologist Art Poyer found an exquisitely preserved porcupine skeleton in a Florida limestone quarry, they were well aware of its significance. “When they first brought it in, I was amazed,” said Bloch, senior author of the study. “It is so rare to get fossil skeletons like this with not only a skull and jaws, but many associated bones from the rest of the body. It allows for a much more complete picture of how this extinct mammal would have interacted with its environment. Right away we noticed that it was different from modern North American porcupines in having a specialized tail for grasping branches.” By comparing the fossil skeleton with bones from modern porcupines, Bloch and Vitek were confident they could determine its identity. But the amount of work this would require was more than one person could do on their own in a short amount of time. So they co-created a paleontology college course, in which the only assignment for the entire semester was studying porcupine bones. “It’s the kind of thing that could only be taught at a place like the Florida Museum, where you have both collections and enough students to study them,” Vitek said. “We focused on details of the jaw, limbs, feet, and tails. It required a very detailed series of comparisons that you might not even notice on the first pass.” The results were surprising. The fossil lacked the reinforced bark-gnawing jaws and possessed a prehensile tail, making it appear more closely related to South American porcupines. But, Vitek said, other traits bore a stronger similarity to North American porcupines, including the shape of the middle ear bone as well as the shapes of the lower front and back teeth. With all the data combined, analyses consistently provided the same answer. The fossils belonged to an extinct species of North American porcupine, meaning this group has a long history that likely began before the Isthmus of Panama had formed. But questions remain as to how many species once existed in this group or why they went extinct. “One thing that isn’t resolved by our study is whether these extinct species are direct ancestors of the North American porcupine that is alive today,” Vitek said. “It’s also possible porcupines got into temperate regions twice, once along the Gulf Coast and once out west. We’re not there yet.” Reference: “An extinct north American porcupine with a South American tail” by Natasha S. Vitek, Jennifer C. Hoeflich, Isaac Magallanes, Sean M. Moran, Rachel E. Narducci, Victor J. Perez, Jeanette Pirlo, Mitchell S. Riegler, Molly C. Selba, María C. Vallejo-Pareja, Michael J. Ziegler, Michael C. Granatosky, Richard C. Hulbert and Jonathan I. Bloch, 27 May 2024, Current Biology. DOI: 10.1016/j.cub.2024.04.069 The study was funded by the U.S. National Science Foundation. Jennifer Hoeflich, Isaac Magallanes, Sean Moran, Rachel Narducci, Victor Perez, Jeanette Pirlo, Mitchell Riegler, Molly Selba, María Vallejo-Pareja, Michael Ziegler, Michael Granatosky and Richard Hulbert of the Florida Museum of Natural History are also authors on the paper.
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